Raw data for multiple endpoints from publicly available reports on Daphnia magna Reproduction Test or Fish Early-Life Stage Toxicity Test could not be obtained through internet searches. Therefore, the analysis was conducted using simulated data from a Daphnia magna Reproduction Test. We encourage users to apply this analysis simultaneously to their own actual datasets.
ToxGenie’s NOEC and LOEC Estimation Analysis Results for Multiple Observation Endpoints
The analysis was performed using the simulated data described above, and the ToxGenie estimation results for NOEC and LOEC for each observation and measurement endpoint are presented in the report below.
The statistical analysis method described above can be applied not only in the field of environmental toxicology but also in General Toxicology Test, including physiological and hematological endpoints in Acute and Chronic Toxicity Tests, as well as Carcinogenicity Tests, Reproductive and Developmental Toxicity Tests, Neurotoxicity Tests, and Immunotoxicity Tests. However, it is essential to accurately apply NOAEL (No Observed Adverse Effect Level) and LOAEL (Lowest Observed Adverse Effect Level) specific to each test endpoint.
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